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Oxidation typically involves free radical-induced modification of amino acid side chain groups (e. , sulfhydryls and amines), peptide bonds, and intramolecular. Protein oxidation is defined as the covalent modification of a protein induced either directly by ros or indirectly by reaction with secondary by-products. Protein oxidation definition: any of a large group of nitrogenous compounds of high molecular weight that are essential. Protein peroxides can oxidize both proteins and other targets. One-electron reduction results in additional radicals and chain reactions with. In biological environments, this is often manifested as an increase in the number of bonds to oxygen. Proteins are oxidized as a response to oxidative stress,. Protein carbonylation is a stable modification induced by ros via three pathways: direct oxidation of protein-bound amino acids, oxidative cleavage of the. 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